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Ipamorelin

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Ipamorelin (development code NNC 26-0161) is a synthetic pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, in which Aib denotes alpha-aminoisobutyric acid and D-2-Nal denotes 3-(2-naphthyl)-D-alanine. Its molecular formula is C38H49N9O5, corresponding to an average molecular weight of 711.9 g/mol, and it is registered under CAS 170851-70-4. Two of the five residues are non-proteinogenic and two carry the D-configuration; together with the C-terminal carboxamide, these features confer marked resistance to exopeptidase hydrolysis and distinguish the molecule structurally from the far larger growth hormone-releasing hormone analogues, with which it shares no sequence homology. Ipamorelin is typically isolated as an acetate or trifluoroacetate salt and presents as a white to off-white lyophilized powder that is readily soluble in water and in dimethyl sulfoxide.

Ipamorelin has been characterized in vitro as a selective agonist at the growth hormone secretagogue receptor 1a (ghrelin receptor), with receptor selectivity and pituitary secretory profiles established in isolated rat pituitary cell preparations and in rodent tissue systems. It has been studied in rat models in which longitudinal skeletal endpoints, bone mineral content in adult females, and bone-formation indices under glucocorticoid exposure were the measured variables. Gastrointestinal transit parameters have been examined in a rodent model of postoperative ileus, and body-mass and emetic endpoints have been assessed in ferrets exposed to cisplatin. Nociceptive thresholds have been investigated in rodent visceral and somatic preparations, and hypothalamic-pituitary-gonadal axis parameters have been examined in a cichlid fish model. Biophysical work has characterized its secondary structure, thermal stability and interaction with model membrane systems. HMD Scientific supplies this compound as a reference material for laboratory research only; it is not a drug, food, cosmetic or dietary supplement, and it is not intended for human or veterinary consumption.

For research and laboratory use only. Not for human or animal consumption.

These products are not intended to diagnose, treat, cure, or prevent any disease.

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Synthesized in the USA

Produced and lyophilized in a domestic facility operating under documented quality-control practices.

Sealed and tamper-evident

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Specifications

Synonyms	NNC 26-0161, NNC-260161, ipamorelin acetate
CAS number	170851-70-4
Molecular formula	C38H49N9O5
Molecular weight	711.9 g/mol (average)
Sequence	Aib-His-D-2-Nal-D-Phe-Lys-NH2 (2-methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide)
Appearance	White to off-white lyophilized powder
Solubility	Readily soluble in water and in dimethyl sulfoxide; sparingly soluble in hydrocarbon solvents
Storage	Lyophilized powder stored at -20 °C, desiccated and protected from light; -80 °C for long-term storage of the sealed vial
PubChem CID	9831659

Selected literature

Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH European Journal of Endocrinology. 1998 PMID 9849822 doi
Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H Growth Hormone & IGF Research. 1999 PMID 10373343 doi
Svensson J, Lall S, Dickson SL, Bengtsson BA, Rømer J, Ahnfelt-Rønne I, Ohlsson C, Jansson JO Journal of Endocrinology. 2000 PMID 10828840 doi
Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H Growth Hormone & IGF Research. 2001 PMID 11735244 doi
Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C Journal of Experimental Pharmacology. 2012 PMID 27186127 doi
Lu Z, Ngan MP, Liu JYH, Yang L, Tu L, Chan SW, Giuliano C, Lovati E, Pietra C, Rudd JA Physiology & Behavior. 2024 PMID 39043357 doi
Gouda M, Ganesh CB Animal Reproduction Science. 2024 PMID 38996787 doi
Králík F, Kvíčalová A, Salaďáková A, Kuchař M, Setnička V Chirality. 2026 PMID 41555539 doi
N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B Journal of Experimental Pharmacology. 2020 PMID 32801950 doi

References are provided for scientific context only. Their inclusion is not a representation about any property, effect, or suitability of this material for any purpose.