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PT-141
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Bremelanotide, catalogued in the research literature as PT-141, is a synthetic cyclic heptapeptide of the melanocortin class, structurally derived from the His-D-Phe-Arg-Trp core pharmacophore of the melanocyte-stimulating hormone family. Its covalent structure is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH: an N-acetylated norleucine residue precedes a macrolactam ring closed between the aspartate side-chain carboxyl and the lysine side-chain amine, and the peptide terminates in a free carboxylic acid rather than a carboxamide, which distinguishes it from the closely related cyclic lactam melanotan II. The molecular formula is C50H68N14O10 and the average molecular weight of the free base is 1025.2 g/mol (PubChem CID 9941379; CAS 189691-06-3). The free base is a white to off-white lyophilized solid; the arginine, histidine and free-acid functionalities give a highly polar, water-soluble peptide, and the substance is frequently catalogued as an acetate salt.
The compound is characterized in the literature as a non-selective agonist across the melanocortin receptor subtypes, and it recurs as a comparator ligand in structure-activity studies of macrocyclic melanocortin scaffolds assayed in receptor-transfected cell lines (Yuan and Tao, 2022; Merlino et al., 2026). Its degradation chemistry, including epimerization pathways, has been characterized analytically by LC-HRMS/MS with accompanying computational modelling (Yuvaraaj and Sharma, 2026). In cell-culture systems, melanocortin-receptor-dependent changes in survivin expression and cell viability have been examined in glioblastoma lines (Suzuki et al., 2024). Non-clinical central nervous system pharmacology has been reviewed for rodent models (Pfaus et al., 2007), and behavioural and neural-activation endpoints have been examined in Syrian hamster models (Borland et al., 2025).
This material is supplied as a reference standard for in-vitro and analytical laboratory research.
For research and laboratory use only. Not for human or animal consumption.
These products are not intended to diagnose, treat, cure, or prevent any disease.
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Specifications
| Synonyms | Bremelanotide; PT141; PT-141 free base; bremelanotidum; Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
|---|---|
| CAS number | 189691-06-3 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.2 g/mol (average; PubChem computed, free base) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine, (2->7)-lactam) |
| Appearance | White to off-white lyophilized solid |
| Solubility | Highly polar cyclic peptide bearing arginine, histidine and a free C-terminal carboxylic acid; soluble in water and aqueous buffers. PubChem lists no experimental solubility record for this entry. |
| Storage | Lyophilized solid held at -20 C or below, desiccated and protected from light. Analytical work has documented epimerization as a degradation pathway, so exposure to elevated temperature and to extremes of pH is minimized in laboratory handling. |
| PubChem CID | 9941379 |
Selected literature
- Pfaus J, Giuliano F, Gelez H J Sex Med. 2007 PMID 17958619 doi
- Yuan XC, Tao YX Biomolecules. 2022 PMID 36291616 doi
- Suzuki S, Kitanaka C, Okada M Anticancer Res. 2024 PMID 39197897 doi
- Borland JM, Kohut-Jackson AL, Peyla AC, Hall MA, Mermelstein PG, Meisel RL Neuropharmacology. 2025 PMID 39793696 doi
- Merlino F, Jia L, Boccino I, Carotenuto A, Tammaro F, Santoro F, Thompson PE, Grieco P J Med Chem. 2026 PMID 42340853 doi
- Yuvaraaj VK, Sharma N Anal Methods. 2026 PMID 42485063 doi
References are provided for scientific context only. Their inclusion is not a representation about any property, effect, or suitability of this material for any purpose.